I'm not into pelts, but dedicated to varmint and pest control. I use everything I own from .45-70 to .22-250. My .308 is probably the most reliable. I don't have a problem poping a fox with an 06. The deader the better. It's kind of early to tell for sure, but I believe the .308 is proving to be more accurate over long distance than the .22-250. It is usually windy here, and I believe that is most of it.
I don't mean to come on as a hard case, but I'm a farmer, with cattle, horses, chickens and dogs and cats. Varmints for me a just trouble. We have bears (two here yesterday), wolves, now cougars, coyotes, fox, skunk, raccoon, woodchucks , porcupines and weasels. It is almost a constant battle. That doesn't include the starlings and pigeons always trying to nest in your barns.