However some while back I saw an article but Layne Simpson I believe where he decided to put the .224" bore to the test on deer. I seem to recall he was using it on crop control deer kills and ran up a pretty fair number of kills with it.
I returned from South Africa a couple of weeks ago. The PH I hunted with does a LOT of culling. Species include Blesbok, Blue and Black Wildebeest, Springbok, Zebra and every thing else that needs culling. His weapon of choice; a rifle chambered in 22-250. He uses it for head shots at up to 400 yards. He told me that he is on his third barrel in the rifle he is using now.
On my trip, I also met a guy from Alaska. Since I'm going there this fall, we had a discussion on legal calibers for deer hunting, etc. Native Alaskans frequently use the likes of the 223 Rem. on Caribou, etc. If you use the proper bullet and don't try to shoot a deers heart through its butt, a .224 caliber centerfire works fine.
Bullet placement trumps power.