yu can, if yu know they are in there, suffocate them with a hose from your tailpipe into the den. ive also heard of pouring gasoline down a garden hose stuck deep in the den then plugging the den with dirt. the fumes will get them.just make sure your plug any holes the fumes can escape from around the edge of the slab with dirt.i probably wouldnt go to such extremes with any other varmint but ive dealt with rabid skunks a few times and their ferocity will surprise yu.