I'm still waiting for the 500 S&W to be bottle necked down to .17 caliber with a Corbon DPX kicking along at 5,500 fps to put down a whitetail!! Good thread, though and deserved unburying. Read alot of good opinions and it is probably one topic that will never be settled. For hogs, elk, and such thicker game I can understand how the debate will widen since the target structure is much different, but whitetail are not that hard to put down given the vitals (Chest Cavity, not neck) is cross-sectioned by any bullet penetrating enough to take out both lungs. Honestly, from the . 38 158gr RNL and the .357 Mag 158gr SJHP, and even the .243 SP, I can't tell much of a difference in affect. They all ran about 40-50yds and died. I've never been concerned about having to have a round that puts them down in their tracks. If I can't track a deer, even with no blood trail, 50 yards then I have no business hunting. How long have whitetails been hunted(over 200yrs).....how long have expanding handgun bullets been around(about 45yrs).....that should give you some insight. Most have been black powder, low pressure loads. My opinion, put me on my bow blinds with a .45 Colt and the Remington 225gr SWC factory (900+/-fps) and I will bring home venison. It's amazing what bullet/ammunition manufacturers want people to believe about handguns! My last two deer this year were taken with a S&W Model 28 Highway Patrolman .357 using standard Remington 158gr Semi-jacketed-hollowpoints. The gun is 53yrs old and the bullet style about 40+yrs old and the end result is meat in the freezer X 2. This was my old service/duty load and it works just fine, though I carried mine in a Model 19. Good huntin' fellas, just my thoughts!!!!