If you are using a ball or fine powder like H414, H380, H332, H335, maybe Varget if your measure is any good at all, you can set it to throw a certain weight and be good to go. IF YOU HAVE A GOOD CONSISTANT MOTION when you make your charging stroke and keep the powder level in the reservoir kinda consistant. FWIW, I do: Position the empty case, lift the handle, two light taps, lower the handle, two light taps. Set the filled case aside, position the new, lift the handle, two light taps, etc. weigh every 10th charge.
If you are loading hunting ammo with large cases (30-06 and larger) and using stick powder, usually the PERCENTAGE of variance from the desired charge will be small enough to be a non factor for hunting purposes.
Of course, if you're the sort that is shooting your stuff at red line charges, everything should be weighed and double checked, IMO.