You'll get the fastest kills when DV is held to not more than 130 maximum, with 125 being optimum max. This is real easy with the WFN and it's .360 meplat, and the bullet is accurate. Going heavier with wider meplat is not an advantage, but a disadvantage from several dirrections. It will not be as accurate at any range, recoil will be far more punishing than with the above adaqute loading, and penetration will not be as straight with a wider meplat.
If you want to use the most pleasant to shoot load, with superb killing power in a 45 revolver, use my 300 gr WFN loaded to a mild 1200 fps. Game up to large bear act like they have been hit by lightening with this power.