Big Bullets...you got to love them. :^)
Man vs. beast-
I carried a .44 ruger vaquerio in South Africa & in Elk/Bear country. I went to a rubber grip that cover the backstrap and with 320gr. HC Cor-bon it wasn't hard to get a second shoot off with realative accuratcy. And at 38+ oz. it wasn't a problem wearing it for 12-14 hours a day. I feel a good soild revolver is fine in the back country, very little to go wrong and besides if you have to defend your self against a preditor, reloading is an option anyway.
The downside was that it seemed trhat a few rounds shock that gun to core loosing most of it's screws.
I've since trade it and a redhawk for a Freedom Arms casull. When a full house load isn't need, Elephant stampeds not withstanding, a very hot .45 load can approach .44 mag power.
Had I ordered this one, I would have went withh .44mag, but the trade was too good to walk away from.
Man vs. Man -
You can shoot .44 spl & some "Light" .44 mag. loads that are on par-with .45 acp. and therefore should be more effective, God forbid you needed them to protect you & yours in the home.
In regaurd to the comment about the lower ranking of the .44 mag for SD, I'd agree if you taking in terms of all shooters.
Big Bore owners only come in two flavors. Ones that master the weapon and those that trade or sell them(Like my friend with the casull).