I have shot them for many years...must be 5 or 6 now? Almost since they came out I think.
Both of my Omegas like them at 110gr FFg 777 (2100 fps). I never tried any other powder with them. In my main gun (which has been accurized) I shoot sub-MOA with them. This load is fairly flat for a ML, I practice with them out to 400 yds where groups are still MOA. I want to try them further but they are pretty slow by then and hunting anything larger than a groundhog at that range would not be for me.
I have taken deer with them from 10 to 338 yds. None have been lost. They expand well, most shots are pass-thrus, including the 338 yd shot (bang-flop). Occasionally if I hit both shoulders in excess of 150 yds I will find the bullet under the skin on the offside shoulder. The lead has sometimes separated from the jacket, but only exiting the offside shoulder after punching a ton of bone (lead exits, core stays under skin). I do not consider this bullet failure as it has always done its job well first and this only happens plowing through every bone in both shoulders.
Most deer have dropped, a few have run a short distance. None far enough to think they suffered less than sufficient damage.