I have the wood stocked vanguard in 257 Wby. It is very accurate with 115 gr Nosler ballistic tips and RL-22 powder. It is also very heavy, I mean like stupid heavy. It weighs more than my wood stocked Win 70 30-06 or 338 win mag. 8 pounds without scope is ridiculous for a quarter bore "sporter" rifle. Maybe someday I'll restock it and take some weight off. I have no complaints at all about its fit, function, or accuracy. It's just too heavy. I really don't like the "factory" synth stock that comes on the vanguard, but maybe an aftermarket one would suit me better.
I also have an old German made 375 Wby mag, from the 50's. Classic rifle, classic "safari" lines. There's no comparison between the hand made and hand fit German Wby, and the modern, mass produced Howa rifle. Not trying to start any "Howa bashing", but it's just from a different era.
I seriously considered getting the "real" Mark V Wby in "true" Wby design, wood stock, shiny finish, all that. But what I was really after, was a long range, flat shooting, hard hitting Coues deer hunting rifle. I had the cartridge made up in my mind long before I decided on the actual rifle. The thought of tearing up a "real" Weatherby rifle, costing 1200-1300, all shiny and pretty, really put me off my food for a while. Some of the places I hunt Coues deer in S. AZ are very rugged, and even the grass has thorns and claws that rip up clothes and gunstocks.
I have seen the limited production Remingtons in 257 Wby that GB is talking about. Unfortunately, I already had my vanguard when I handled the Remington. If I had it to do now, I'd probably by the Remington. It swings and handles better, it's lighter, felt like about a pound lighter if I recall correctly. I seriously doubt it would have been one bit more accurate than my vanguard however. I'm sure it would shoot plenty fine for a hunting rifle.
I guess if you want a "Bucket List" Weatherby rifle, then there's only one choice, that's good old Roy's classic Weatherby Mark V, wood stock, shiney finish, classic Wby lines. Anything else will still shoot, but it won't be worthy of your "Bucket List".