Personally I have always likes a 30-30. When I was growing up a 30-30 was the "Mac-Daddy" of deer rifles, but over the years they seem to have fallen out of favor. At least here in Louisiana & I never see single shot rifles around here, except for muzzleloaders. The thing that I can't figure out is, people will hunt with muzzleloader, but not a single shot rifle. Their reason being is that you can't get off a 2nd shot fast enough. How long does it take to reload a ss rifle? 10-15sec? Compare that to a ml, which could take 30sec-1min. If the shooter is good! On top of all that, how many times do you get a 2nd shot at a deer? Sorry about my rant, I get like this when stupidity over rides common sense.
Back to the subject at hand. Snmann is right, with a 243 placement is everything. That's why I was thinking about a 7mm-08. It has a little more knock-down to it. My wife has taken several deer, including a nice 8pt, but she still gets a little "buck fever" & sometimes her placement is a little off.