I would look for a good S&W Model 17 for iron sights. If you want a scope or red dot optical sight, I would go for the S&W 617. Some of the earlier models are not drilled and tapped for a scope mount. I have several revolvers with UltraDot 30 red dot sights and they do very well. I also use them on autos, but revolvers are my favorites and I love red dot sights. The Weigand bases fit very well and will accept Weaver style rings.
I agree with Graybeard to a degree. I don't think any handgun looks quite right with an optical sight, but they sure do shoot. I set up a group of handguns with iron sights and another with red dot sights. I usually shoot a trio of .22, .357 and .45AR. I shoot a lot better with the red dots, but I am 68 years old and the eyes are not what they once were.