Hey Big Gun,
I have a 350 Rem Encore in pistol configuration. Mine is a Fox Ridge barrel that I had throated long to seat bullets a little farther out. It is ported with TC's rubber grips. It is a handful but not excessive. I would highly recommend the chambering for anyone looking to tackle elk, bears, moose, Africa.
I've done a lot of testing in it and found mine likes IMR 4320 with Nosler 225 Bal Tips. It gets a chronoed 2450 fps and right at 1" at 100 yards with this load. I've had loads go over 2500 fps but not as accurate. My load produces ~ 3000 ft/lbs of energy putting it in the 30-06 rifle class - alot of elk and moose have been killed with the '06.
There are better up close hammers and their may be better long range hammers but I think the 350 comes close to being ideal in both categories. If you can shoot full power 44 mag loads in a revolver, you can shoot the 350 in a braked Encore. Hope this helps.