For years my two varmint handguns were a Ruger Single Six with the magnum cylinder, or my 357 Blackhawk. Both have accounted for slews of varmints from small game to groundhogs, and predators.
My dedicated varmint revolver now is my 32 magnum. It started life as a stainless Ruger Single Six 22/22mag, but I took it new NIB to Dave Clements, and he converted it to 32 magnum. He put a 5.5" Douglas barrel on it, made a taller front sight, made a slightly oversized line-bored cylinder for it, converted it to centerfire, and gave it a few more TLC touches, installed a set of Lett silver/black laminate grips, and ingraved my name on the bottom of thr grip frame. This little "Baby Magnum" as I've come to call it will out shoot a lot of 22 rifles I've owned, and has racked up a pretty good tally of small game, and predators in the last couple seasons.
I mainly shoot my Saeco SWC bullets in it. They weigh 97.9g + or - .2g, and at 750 fps thump squirrels, and rabbits like a hammer. This combo has also accounted for a few dozen coons, and possums. This same bullet pushed to around 1200+ fps is a very hard hitting load on coons, groundhogs, and such. I've also used 85g XTP-HP's, and 90g Sierra HP's at around 1200+ to kill quite a few critters, and they have awsome terminal performance, especially the 90g Sierra.