Stimpy is correct, what may work wonders in ours could be trash for yours.
That being said, be sure to try different bullet profiles. Some barrels just dont like boat tails while others didn't care for plain base bullets.
I have had a couple 22-250's, both have shown a preferance for the 55gr using H380 powder. (The name of this powder IS the load when using a 55gr bullet.) I have also had some good results with the Hornady 60gr SP.
CW