Hi,Shooting 44 magnum rounds through your 4-5/8" Ruger is no problem, that's depending on how many your planning on shooting,I usually go through about 20-30 rounds are so before I switch over to .44 Special rounds,the .44Special rounds take a less toll on my hand and wrist,sometimes i'll only fire 12 rounds through before I switch over,the 44 Special seems to be more accurate too around 25 yards the Ruger can handle the Magnum rounds all day long,It's a great revolver,and very well made. when are you going to post your Vaquero,I might be interested. copshop78@yahoo.com