I have had good sucess with a combo of handloads and store bought ammo that shoot to the same zero, so it makes it easy if I run out of time and can't get to loading for a season
Handload WFN 280GR hardcast over 20.5 GR H110
Bought Hornady XTP 300Gr
I find tht the store bought stuff shoots a little more accurately, but all group in the same area. When sighted or 25 yards, I cn shoot offhand to 50 without any compensation to speak of for deer. This is with the same pistol you are using.
I like the hardcast on pigs, and have used them successfully on deer. The hollow point seems to have a more immediate effect, but either brings them down within 50 yards.
If deer is your only game, the 240GR XTP is a good choice, as it offers enough penetration with a little flatter trajectory. With a scoped gun, 100yd shot is possible.