I really like my 221 FireBalls, I have 3. They are plenty for coyote out to 200 yards, maybe more with the proper bullets. Down side is ammo is hard to get, you basically have to reload. You can not get a 221 FB in a Handi rifle, unless it is custom. I would opt for the 223 for several reasons. Cheap ammo , it does not matter if you buy or reload, it is one of the cheapest. A very wide selection of bullets again if you buy ammo or reload. It has a range of 300+ yards with accuracy pleanty good enough for coyotes. As mentioned the wide variety of bullets lets you choose the type of hunting you do. Do you want to save pelts; get a light bullet that will go in small and not penetrate all the way through. If you just want to put them down then use a bullet that will go all the way through and take out a golf ball sized hole on the other side. You can load it down (2500 fps) or up fairly fast (3700 - 3800fps 40 grain bullet). The real trouble is, there are many solutions to your problem, from a 17 Hornet to what ever (even a 45-70). Pick one that you can purchase in a Handi and you like, you really can not go wrong. Good Luck and Good Shooting