I just do not know how the 30-06 can be beat, unless the recoil is too much for you. It is very versatile, you can buy ammo where ever ammo is sold any where in the world. It will handle anything on the North American continent except the big bears and will even do those if you can put the right bullet in the right place and have enough confidence to reload and get off another quick well aimed shot. If the recoil bothers you then the 7mm-08 will do most every thing up to moose and even those if again you place the right bullet in the right place. If you want to really stretch it out here, then the 280 sure has some slick (high BC) bullets that will reach out a looong ways with authority. Now that I think about it some more; they are all good, and any one one of them will shoot well and I have heard of them all shooting well. I say pick the one you want, you can always add a barrel or just buy another one. If you are going to reload, you may want to think about the 30-30 as a deer rifle. You can use pointy bullets in a Handi, they have a good reputation for accuracy, easy to load for, cheap and you can buy ammo just about any where if you run out and very low recoil, that just about anyone can handle. If you are not going to be shooting over 200 yards and not planning to go Kodiak hunting, the 30-30 may serve you well. No matter which one you pick, they can shoot well. Good Luck and Good Shooting