That's a "loaded" question, isn't it?
Yeah, that was cheesy.
Anyway, I've found them to be as accurate as any other bullet for me. I shoot factory ammo exclusively. The caveat is that I don't expect EVERY bullet in EVERY gun to produce groups you can cover with a dime.
1st in 30-06's (the caliber I have the most experience with).
While I don't shoot them personally, I've seen exceptional groups from the Winchester Ballistic Silvertip 168gr 30-06. It seems that every gun I've seen them used in shoots tiny groups, from Ruger 77's to Winchesters, and Rem. 700 and 710's. The only gun I've seen that won't shoot them is my 7400.
Same thing with the 180gr Accu-Bond and the old 180gr Failsafe loads (not a Nosler bullet, but oh well). I had a Rem. 700 that would put ten of the Accu's in a group less than 1". My old Win. M70 would put 5 of the Failsafes in 5/8" all day long.
These same guns also shot very well with the Rem CL, especially the 165gr load. Not all groups were bugholes, but all of them were under 2". The 165gr load was the 3nd most accurate in my 7400 30-06 at just under 1.5". The Hornady 150gr SST is the most accurate at under 1" and the 180gr Failsafe is just over 1". I've had 8 different 30-06's and the 165gr CL was always in the running until I found THE load for a particular gun. It wasn't ever the most accurate, but I'd have to rate it as probably the most consistent.
2nd in .308 (the next caliber I've got the most experience with)
The 150gr Rem CL is the most accurate factory load I've used in my .308's other than Federal 168gr Match ammo and some Winchester LE only match ammo. That would be 1 Vanguard Varmint Special, 1 Savage 16 Weather Warrior (the old style stiff fluted barrel with the break on it), 2 Savage 10FP Tacticals (one 20", one 26"), a Remington 700 LTR (it was the only bullet that would shoot under 2", that gun SUCKED, but that's another story) and a H&R Ultra 22" and a couple of Rem. 700 ADL's. All of the other guns shot the CL under an inch, and in the Savage 16, it shot less than 1/2" consistently (better than the match ammo).
3rd in 25-06 (I've had two)
The only load I've ever used in either of my 25-06's is the 120gr CL. I think that this load for the 25-06 may be close to perfection. In a H&R Ultra it averaged around 3/4", best group with it was less than 1/2". In an Encore, it was less than an inch all day long. Between my friend and I, we've taken probably 8 deer with the load, which isn't a huge number, but it was enough to totally hook me on it. Every deer we've shot has been a complete pass through, regardless of the angle and distance, whether buck or doe. Biggest deer was about 175lbs, quartering on, at about 75yds. Entered right in front of the shoulder and exited the rear ham. What else can you ask for?
Man, typing that got me all excited about another 25-06, one of those S&W I-Bolts is looking might good right now.....
4th in .243
Oh yeah, let the controversy begin. I've had three bolt action .243's and I've killed deer with all of them, as have friends who borrowed them. Again, groups of 1" or less have been the norm, from three M70's and one Encore. Performance hasn't been at the level of the 25-06, but we've not lost any deer because of them. Most of the deer were bang flops. We tracked a 6pt for about 100yds, but my friends shot wasn't perfect....
That's been my experience with them. Honestly, I don't shoot much of the Nosler's, as locally, any of the makers premium loads with them, as well as Federal ammo (the most Nosler loads??) isn't readily available unless I want to drive 40 miles to Bass Pro Shops. I shoot a lot of Hornady and have found it to be probably the most consistently accurate ammo in my guns. But the Remington CL is usually right there too, more than good enough to suit my needs 95% of the time. And EVERYONE around here that sells ammo carries it, from Wal-Mart to Auntie Em's Corner store, so I never have to worry about availability.