I've never shot a 480 Ruger but I consider my scoped 460 S&W Encore with it's brake and 15 inch barrel more comfortable to shoot than an unscoped Contender 44 Rem. Mag. if that's any help. I suspect it's probably comparable to an unscoped, unbraked 480 Ruger.
I had some difficulty coming up with a load that met my requirements for accuracy in my 460 S&W. I finally hit the winning combination with 2400 powder and Hornady 250 gr. SST/ML (the ML stands for muzzle loader) bullets. The pictured 1.5 inch group was shot off the bench at 200 yards. This load has has also been used with great success on Zebra, Red Hartebeest, Gray Duiker, Kalahari Springbok, Porcupine, Cape Grysbok, a Klipspringer (at about 180 yards), a European Fallow Deer, an Impala and maybe some other's I've forgotten.
On the above target, I was aiming at the upper red circle and the gun was right on at 100 yards. The drop from 100 to 200 yards was about 7.5 inches giving an estimated velocity of 2,350 fps.
If you get a 460 S&W Mag. be sure to go with a durable scope. The torque from this cartridge is very hard on scopes.