Anything wrong with the J-Frame .38? How about a J-Frame .357? Compact, light, easy to use while stressed, durable, repairable, and you can even get pink grips (should she be of the pink persuasion). No stovepipes, jams, levers and buttons, safeties, or parts that can get separated from the handgun. And a cartridge with an excellent reputation for stopping people.
Or do you just think she wants something different?
-Don