I use Winchester 760 for some favorite loads, and as part of the load data I note the micrometer setting to use for my powder charges. I just got a new jug of 760 and the same micrometer setting I have been using all along now yields a charge weight one grain heavier than it was with the old lot of powder. This caused a problem when I topped off the powder measure with the new stuff and it affected my charge weight.
During the same session I started using some new brass with a new lot of Nosler BTs. My overall length was about 5 thousandths longer than with the old brass and an earlier lot of the Noslers.