If I only had to have one, unique would be the way to go. I do really like titegroup, but titegroup is no good for hot loads with large bullets, doesn't get you much velocity. Unique gets you a little more speed in large calibers. Titegroup is the most economical.
H110 and 4227 are a good way to go if you want to shoot hot, but they take a lot more powder.
For all around use though, you can plink, hunt, and play with whatever caliber you please using unique. Just be ready to clean your gun ;-)