I use 70 gr of FFF in my CVA hawken. It is 50 cal, 1/66 twist, 26" barrel. The 70 grains is a very accurate load, leaves little residue and is very easy on the shoulder with patched RB. This load is good for pass thru lung shots out to 50 yds, but doesn't have enough oomph to pass through both shoulders.
I shot a 6 pt three years ago at 20 yds with this load. Hit square in the shoulder, he pulled up his near side leg and ran off using the other three. Never heard a crash. Got down and checked for blood. Not a drop. Two buddies of mine came over and we looked for about 40 minutes, got real lucky and found the buck piled up in thick brush about 80 yds away. Very little blood coming out the nostrils.
The round ball punched thru the near shoulder, splintered some bone, punctured the lungs and came to rest inside the muscle of the far shoulder. It definitely killed the buck but left no blood trail.
This load is a lung shot proposition for me now. I want to see the blood trail coming from the 50 cal holes.