Yes, depending.
If it's a Trapper (16" bbl, sight in barrel dovetail, no ramp), some were soldered or brazed in, and are difficult to remove via normal methods, while others pop right out.
Support the underside of the barrel (if the sight is installed directly in a barrel dovetail) or the underside of the ramp, with the rifle laid on it's side, loading port down. Be sure to leave room in the area directly under the sight dovetail (for the sight to move into when it's drifted).
Drift/drive the sight blade out, using a fairly heavy hammer (not a sledge) and a non-marring drift pin, like the brass pin from a house's interior door hinge. (any brass marks are easily removed later).
Flip the rifle over, support it as noted above, and install a replacement sight blade likewise, from the opposite side.
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