Kody, in most of the load data I have seen, the .45 will shoot a 200 or 180gr bullet a little faster and flatter that a 50 with the same bullet. But at 100 yds with the 45, your talking an inch or so and still less energy than the 50. Meat and potatoes testing... the 45 with a 200 gr shockwave killed them just as dead as the 250 gr from a 50, usually just as fast, at the same ranges (175 yds was my longest shot and it was from the 45). If my Black Diamond wasn't such a pain to clean, I would have kept it (wish I did!).
Denny