Personally, I'd rather have a bullet that doesn't exit as well. That's why I have .223's and a 6mm Rem. However, given the parameter of using a .308 as a varmint/predator rifle this will happen on most every "varmint" out there. So, in addition to carefully chosing your shots to ensure that there is adequate "backdrop" to stop a bullet that passes through; I included the "lightly constructed" verbage. As we all know the more lightly constructed bullets will be less likely to pass through the intended target. Additionally, said projectile will more likely break up on impact with the ground, brush, trees, etc instead of continuing on to cause damage somewhere else. So, careful bullet selection alongside proper shot selection should help ensure the safety of all except the target. I would have no problem using my .308 as a predator rifle. Actually, with the exception of my AR, it's probably the best I have due to it's size and weight. It's significantly lighter and shorter than my full-sized Remingtons, Rugers etc. Oops, got off topic, went into rifles again instead of cartridge. As for the .308, I wouldn't down load it at all if I were trying to make 300 yard varmint/predator rifle out of it. Now there are some 125 gr reduced recoil loads for it (Federal I think) that would make a good varmint round but you'd have to know your shots to be good at 300. Might be an option.