I haven't loaded for either the 460 or 375 Ultra Maz, but have played with a 458 Win mag quite a bit, in a Ruger #1, and learned that it could come back pretty hard when I 'powdered the fanny' of the bullets a bit too heavy! Unique is way too fast a powder in my opinion for large cartridges. Better choose a ball rifle powder that fills the case at least halfway, so you can't get a double charge by accident. (They are NASTY noisy with a big cases!) The slower powder will get things started a lot softer, which means a less sharp recoil rap, which is easier on the lead bullet also.
If you choose to use Unique, it will sure use a lot less powder than a slower ball powder. Just be sure to charge all cases in a loading block, then check each with a stick to be sure powder level is the same in each before loading the bullets. That's the only sure way I know of to prevent a double charge from happening someday. In case I'm not getting this double charge issue through solidly, it is better to sit on 10 sticks of dynimite and set her off, so you know you wont's suffer. If you double charge that 375 there is some chance you won't die! I blowed a 30-06 up about 45 years ago, and it seems I can still hear the report bouncing around out there! It was a double charge of 2400 behind a military ball bullet, made by someone else. I had just the forend in one hand and the butt stock in the other when the dust and shrapnell settled.