Weber:
My thoughts at random.
You don't state what game you will be hunting.
IMO if you stay within the type of game the 243 Win is designed to hunt you don't need Partition bullets.
100gr Sierra is a hard bullet. My wife and myself have used it on mulies, and in one case on a moose and Whitetail. The only bullet recovered was from the moose and that only because it hit the shoulder blade, back bone and piled up on the inside of the other shoulder.
I lost the White tail, it was a 45 deg from the front shot, very little blood and then nothing. We had a large group of people searching with me. A dog would have been great, but there was none available. the mulies ran a good 50 to 75 yards with double lung penetrations. It was a very accurate bullet, that is why we had stayed with it. My wife no longer shoots a .243 having "graduated" to a 284 Win. and I have just purchased a new one and will use a different bullet.
What I read here, in other Forums and what I have seen out in the field, the Sierra 85 gr. HP sems to make an outstanding hunting bullet for deer size game. I'd give it a try. My conditions here are all close range so I will use RN's.