To sum it up,
454 cal is best for long range (relative to handgun) as it can drive a 260gr bullet fast enough so it has useable trajectory out at 150-175 yards. It can also drive 335gr bullet fast enough for heavy animal hunting (buffalo). This chambering tends to recoil pretty fast with light ammo driven fast. It's scary for first time big bore shooters. Flinch factor is +++.
The 480 does not fare very well with light ammo and is really best with 325 - 400gr (375 is optimal) for closer shots with extreme penetration and terminal performace. Think of the 480 as a Limbaugh short. It does not have the extreme heavy recoil, so it is a little easier to master shooting, but it is far from a cream puff (especially in an unported ruger)
GB is right, a 44mag will do everything you are asking, at about 1/2 - 2/3rd the price for ammo. Haven't met a deer a 44 would not kill. I shoot 280GR hardcast and 300GR XTP. I'm thinking of developing a 225gr load with the new hornady ammo for longer range for deer.