I am working up a load for my 270wsm at the moment. I am using Hybrid 100v. whatever load I find works best for my gun may not be the best load for your gun. I recommend you start with a manual for the bullet you want to try (Nosler), begin with the starting recommended load and load 5 rounds, then increase in .5gr increments and load 5 more rounds, continue until you get to the max recommended load or until you groups start opening up whichever comes first. If the particular powder you tested doesn't give good results, try another powder. ANY component you change, start over with the lowest recommended charge.
good luck, finding that special combination is very satisfying.