I've had my .45/410 14" T/C contender for 20 years or so and have never had any accuracy problems with .45 LC. I have shot multiable groups, pie plate size, from a bench rest at 110 yards (iron sights) with no problem - although you can almost out run the bullet. I bought some corbon 300 grain bullets for deer but have yet to try them. Corbon says only to use them in T/C frames and a few others as they nearly match the .44 magnum ballistics out of a 8" revolver. One article called the corbon ammo a ".45 magnum".
I recently purchase some silver bear (russian) .410 slug ammo and it is dead on at 25 yards. Just remember to take out the shot plug before shooting any slug or .45 ammo.
The .410 shot is good out to 30 yards - shot coon, pheasant, squirrel, rabbits, and occassional stray cat. It is great for rabbits as you don't have to fight a bunch of tangles when raising the weapon.