Bucking the heavy bullet trend for deer, I have good luck with the 250XTP in my various .45LCs. Penetration is ample, just as good as the 300 XTPs (not MAGs) I tried. Recoil is less and the trajectory is slightly flatter. I shot one deer with the 240XTPMAG and won't do so again. The bullet exited but expansion appeared minimal at 1300 fps. I don't need 1600 fps for deer.
The best cast bullet for my Trapper is the Lee 250FN. This is a short bullet that mimicks the factory LOA, feeds flawlessly, and has a big meplat to slap hard when it hits skin. It also has about the longest bearing surface of any .45 bullet of similar weight save a true WC, so loading density is high, accuracy is great and leading is minimal. I don't care for CBs for hunting game since the XTPs came out, but this one is IMO the best of its weight.
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