I have 2 loads for my Bisley Vaquero,( 4 5/8") 1 is my "midrange" load, a 250 LFN gc at 1078 fps,tin/lead mix the other is my hunting load, same bullet @ 1278fps, water dropped WW, Titegroup and Lil' Gun respectivley. I set out to have 2 loads that both printed to the same sight picture, I got lucky. My midrange is point of aim, the hunting is 3" high @ 25yds. Funny thing is I really don't use the hunting load for hunting, I like the milder recoil of the midrange load. O.K. real life hunting experience, not much 1 300# hog shot behind shoulder at 25yds, maybe.. maybe ran 30yds (I didn't measure it) but no more. Complete pass thru. My opinion would be you "Will" have the same experience with deer at 1000fps or below down to say 900. I have more experience with the 45 colt w/250 LFN pb. that one will also do what your looking for. CRASH87