Having already mentioned that it is never recommended to substitute components due to unforseen results. If you are going to switch primers, make sure you go milder not hotter. Better to run the risk of snap, crackle and pop then the alternative. Also should be mentioned, when manufacturers publish load data, the recipes they publish are known to be reliable/safe loads with the components called for. What they cannot take into account is local availability. Take my area for instance, the local supplier(walkin to visit, not mailorder) always has Aliant powders, Winchester wads, Winchester 209 and CCI 209 primers, usually has IMR 700-X, & PB. However if you like to Fed 209A, 800-X or Hodgson's Shotshell Powders, it's hit and miss, forget Federal Wads except 12S4. I use Federal Hulls, Green Dot and 700-X(on occasion), Win 209 or CCI 209 primers, and WAA12 or WAA12SL wads because I can reliably get them when needed, leaves alot to be desired in published data sometimes wouldn't you say? So I stick with load data using Fed 209A(the hottest I can get here on occasion) with a rated chamber pressure no higher than 9500PSI, then substitute to Win 209 or CCI 209. On real cold days in January I may get an off sounding shot on occasion, with Green Dot, I know the load is slightly slower then the original data at a slightly lower chamber pressure, but the Grouse, Hare or clay bird rarely notices the difference.