I did that by mistake. Loaded 50 rds. with some 296, and it wasn't till I was back on the reloading bench that I noticed that I had loaded with std. primers. I had shot 40 rds. and didn't have a problem, so shot the last 10 at a later date. Since I was loading for a revolver, I had put a heavy crimp on the bullet. This might have been the reason I didn't have a problem. If at all possible, I wouldn't try it. I have read in a Seirra manual that to go from std. to magnum can be done, just start at the bottom load suggested. If you do try it, be very careful of squibb loads, as you might not be able to ignite the powder and get a complete burn. gypsyman