As you know handgun hunting and rifle hunting are two differnt hunts.
with the hand gun 75 yards is a long shot. under 50 is more common.
At those ranges the 357, 44, and 454 with the proper bullet and velocity will work.
The big flat bullets that work well on game bleed off the already modest velocity quickly and there fore energy.
There is a rule of thumb that you want 1,000 foot pounds at the animal for deer sized annimals and 2,000 foot pounds for elk sized animals.
This is why writters give the pistol caliber and even the 30-30 a hard time as big game guns.
Also with the rainbow trajectories even though a 200+ grain almost 1/2 inch hunk of lead will still do all the damage needed to have deer hanging, the rainow trajectory makes it harger to make good hits with the rifle past the point where you drop well below the 1,000 foot pound mark.