If the chamber throats are the same, or about the same, diameter as the barrel bore it will probably be an accurate revolver when loaded correctly. I like the bullet to fit the throats, as in need just the lightest push to pass through. Sometimes chamber throats on Rugers chambered in 45Colt are smaller than the barrel but it sounds like your Blackhawk is probably sized to about .452" which should be about right with the O.T. cast bullets.