I favor the Colt for it's better balance and ergonomics--trigger, hammer and grip relationship. As does everyone I know. And the Remington will foul quicker than the Colt due to its smaller cylinder arbor. The Colt's arbor is not only larger in diameter, but it is grooved so that it can hold even more lube and the lube can be of a stiffer consistency , too. The Colt was designed with clearances for lubricant and still provide accuracy--it is a true combat pistol in the same vein as the 1911 Colt .45 A.C.P. The Colt rammer is also stronger--the Remington has a thin link and a couple of small pins in it. People always point to the Remington's top strap and say that the Remington is way stronger than the Colt. But there are a great many Old Colts around that are still tight, and even the Italian ones with steel frames last forever. Neither brass framed Colts or Remingtons last with loads that don't faze the steel ones. So maybe that top strap isn't quite as important after all.
Bill Hickok carried a pair of percussion Colt Navys long after not only the Remington was available but reliable and powerful cartridge revolvers were widely available too. This was a man who knew his handguns and whose very life depended on his pistols and he chose the Colts. I expect that he had some very good reasons for this...
However--if the Reminton punches all your happy buttons and feels best to you, there is no reason that I can think of why you shouldn't get one. Your life doesn't depend on your choice(I hope), parts are readily available(VTI Replica Gun Parts is a good source), and you won't be practicing fastdraw with live loads--right? I would go with a Uberti despite the slightly higher cost. Have fun.
