williamlayton and L-Roy: Wm--good question about alternating bullet types but I'm not so certain I would want to do that. As with L-Roy, I favor the heavier bullet as it will penetrate. The hollowpoint may not function properly, may jam fulla stuff and act as a fmj. Soft points don't always expand and may be turned away by impact so as not to penetrate where you aimed. If someone or something is worth shooting once, he or it may be worth shooting twice and if I have to go to that extreme I'm not so certain I would want the second one to be any less effective (actually, to hurt any less).
L-Roy: as for the sight settings on the 38 snubbies, they are still regulated by the factory for the standard pressure original 158 grain round nose police bullet, I believe. The semiwadcutter design has the same point of impact, just a differently designed bullet. All my fixed sight 38s shoot to point of aim at 50 yds, and are just a couple of inches high at 25. I have tried this with 3 different snubbies and a couple of 4" Model 10s using some old WW 158 gn round nose 'golden bullets' (the old ones), 158 gn reloads using factory velocities and powder charges, wadcutter target loads, and the 200 grain Police load and reloads with factory powder charges (less pressure than even the wadcutter target loads). I believe that most if not all pistols with fixed sights were regulated for point of aim impact at 50 yds, consistent with military requirements, as 50 yds was deemed the maximum effective range for pistols, which included 45s and 38s. I believe. HTH. Mikey.