I have used it and the SIERRA 240 .451dia bullets in SAA loads for deer. They worked well enough, expanded well and put venison in the freezer. I prefer a good wide flatpointed lead bullet for this level of load.
Loaded to 1200+ FPS should work OK. But I wouldn't go any higher and maybe even avoid larger bones at close ranges. This bullet was designed for under/at 1000fps performance.
CW