Definately. Get a 180 gr FN (which is the WFN in calibers larger than 38) at .359 diameter. If you use LBT lube a plainbase will get max power or near it from the revolvers, if their bores are smooth. Gas checked will forgive most barrel flaws and allowing about 50 to 100 fps higher velocity at a given pressure, with good accuracy using almost any reasonable powder and charge. Gas checks will be mandatory for the lever guns if you load to full power which is about 1800 fps. Because you plan on a lever locker sometime, let me know, as I cut the nose a little short of the standard .35, so it will feed smoothly.
Most if not all Rugers have room forward of the case for a .4 nose length, which really raises the velocity potential. However, you may not want to bother with a speical mold for your brothers one gun, and he may not even want the extra power which can be obtained with the longer nose, which would be a good 150 fps over a .35 nose. A gas checked .35 nose 180 gr FN is capable of 1400 fps + in 6 inch barrel revolvers.
If the bullet doesn't chamber in any of the guns, size down to 358 or if necessary 357 till it chambers easily. I recommended the large diameter to favor the lever guns, and allow use in 95 % of the revolvers out there, with excellent accuracy. A few revolvers will be found with cylinder throats as tight as .355. If you happen to have one, sizing the bullet down .004 won't hurt performance.
The above velocites are with LBT bullet lube. Most others drag enough in the barrel to reduce velocity potential considerably, some of them well over 100 fps with gas checked and 200 fps with plainbase.