There are sooooo many aspects to accurate loading. Bullet seating depth is one of many variables that can and should be part of your experimentation. Bullet quality, weight, BC, etc all contribute, but is only part of an overall load.
What are you trying to do?
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If you are killing deer, frankly, just load good, safe ammo that shoots well. It's pretty hard to tease out big differences in accuracy as long as you load with a few basic accuracy techniques.
1. Good bullets
2. Appropriate powder
3. Consistent case length and weight
4. Clean, deburred primer pockets
5. Seating the bullets a little off of the lands for good field consistency
If you are loading for bench accuracy with a heaviweight targrt barrel, Kelbly action, etc, then all the little stuff makes a difference. People tend to get way too wrapped around the axle on "acuracy" loads for popping a little meat. FWIW, IMHO.