My personal cary gun is dictated more by what's laying on my desk when I leave the house, than by caliber or bullet shape. Mostly, it's a Taurus UltraLite in 38 special, but sometimes it's a SAA birdshead grip in 45 Colt, and sometimes a Ruger Bearcat in 22LR, depending on what's laying on top at the time, and how I'm dressed that day. The Caliber or kind of pistol carried is not important to me, anything I've got will do the job, if needed.
The old saying,"Ther are no dangerous wepons, only dangerous people", has more truth than any other saying about carry guns. A 22lr in the hands of a person willing and skilled in it's use, is way better than a 45acp in the hands of a person that will hesitate to use it when needed. A baseball bat in the hands of a person that will use it when needed and react instantly to danger, is much better than a 44 mag in the hands of a person that will hesitate to use it when needed.
If you develope the mindset necessary to take a human life to defend yourself, or another, the caliber of the gun you have will not be much of an issue. The mind is your greatest wepon.
Use it.
Greeenriver