I just recently tried the Barnes 250gr XPB in my Ruger SRH. Using a heavy load of H110 (from the Barnes book) the XPB shot tighter groups at 50yds than any of the Hornady XTP bullets that I've been using.
I have been shooting with open sights and it would really take a scope to determine what this loads actual potential is at 50-100yds.
By the way, Barnes sells these bullets in boxes of 20, so the cost to try some is not too bad. It took me a total of 10 rounds to get them in the center of my target at 50yds.
VH