I am using a .45 Knight DISC Elite this season. The load is 120 gr BH209, TC Shockwave .40 cal 200 gr, supplied tan sabot (Harvester light blue .45/.40 works well also), non-FPJ conversion breech plug and Winchester 209 shot shell primer. I am sighted in at 3" high at 100 yards which puts me less than 4" low at 200 yards. I used a similar setup in a .45 Wolverine 209 and took a buck with it at 200 yards last season. Practice, use a steady rest. put the bullet where it belongs and it will work.
Edited - Checked my notes on the powder charge, I am using 120 gr in the Elite not the 110 gr that I had listed earlier.