While you're in all probability right, that the CSA cannoneers knew better than to fire the Whitworth B/L's without the cartridge; I'm always reminded of the 12.75 Blakely that lost its breech in defense of Charleston, because the crew didn't have the instructions on how to load the gun, nor understand the purpose of the air chamber built into the breech.
Excerpt from "Sketches From My Life" by The Late Admiral Hobart Pasha (Augustus Charles, Hobart-Hampden) He was a British subject that served as an officer in the Confederate Navy.
Having had a good look at the positions of the attacking and defending
parties, I went down from the tower and paid a visit to a battery where
two Blakely guns of heavy calibre, that had lately been run through the
blockade in the well-known 'Sumter' (now the 'Gibraltar'), were mounted.
These guns threw a shot of 720 lbs. weight, and were certainly
masterpieces of design and execution. "Unhappily, proper instructions for
loading had not accompanied them from England, and on the occasion of
the first round being fired from one of them, the gun not being properly
loaded, cracked at the breech, and was rendered useless;" the other,
however, did good service, throwing shot with accuracy at great
distances. I saw much that was interesting here, but more able pens than
mine have already described fully the details of that long siege, where
on one hand all modern appliances of war that ingenuity could conceive
or money purchase were put into the hands of brave and determined
soldiers; on the other hand were bad arms, bad powder, bad provisions,
bad everything; desperate courage and unheard-of self-denial being all
the Southerners had to depend upon.
I don't think there is much doubt, that some of the CSA crews manning these B/L's became frustrated with the breech's not functioning properly, and switched to using them as muzzleloaders with (if they had them) the copper gas checks, but this all still leaves the question: Why were the breech mechanisms becoming so fouled? Was it due to poor designing on J. Whitworth's part?