I've thought of that myself.I dont recall seeing caliber markings on plugs from rifles offered in 45 and 50 so they may in fact be interchangeable.I would measure the outer face of the plug and if it is larger than the groove diameter of the finished barrel I'd say it would most likely do fine.I've often thought that a very fine rifle could be made for ball and have the benifits that come with the inline concept.Imagine an octagonal barrel with say, Knight or T/C Black Diamond action/trigger parts.Could even make it a fixed breechplug type ( Thunderhawk type).it could be VERY distinctive and effective in .50,.54 or even .58.Fiddleback maple stock, browned barrel, crescent buttplate and brass fittings....Humm.....