I have both a .45/.410 barrel and a .460 S&W. I wouldn't dream of shooting anything other than .45 LC or shotshells out of the .45/.410 barrel. The .410 barrel an absolutely perfect weapon on Blue Grouse, but as others have mentioned it has relatively poor accuracy with the .45 colt rounds. I've shot .45 Colt, 454 Casull, and full power .460 S&W mag out of the .460 S&W barrel with excellent accuracy from all three. From a recoil standpoint, the .45 LC is a real pussy cat, the .454 Casull is fun but gets your full attention, and the .460 S&W mag is shootable but not much fun for anything but serious hunting unless you're a masochist! I'm going to have to put a brake that barrel some day.