I'm a huge fan of the 480. I sold my 44 and skipped right on by the 45 and 454. I've fired many 454's, 475's and 500's, but don't care for the fast and nasty recoil. The nice thing about the 480 is you get big bullet, big bore performance, ie 400 grs @ 1200 fps, w/o heavy charges of powder and hence heavy doses of recoil.
There is also nothing wrong with using a 480 on small game, I've taken three spruce hens w/ my 480, all w/ 310 gr @ 700 fps. Very effective, but not terribly destructive.
Handloading, and better yet bullet casting as well is needed to get the utmost out of the 480. Not that you need to push the round, but to realize it's potential you need to load your own. Some may recomend more power, but to my thinking, if a 400 gr @ 1200 fps, or a 460 gr @ 1050 fps isn't sufficient, then a little bit more speed isn't the answer. The answer is a large rifle, something that is much more powerful than any practical handgun.